Welcome to SymCel
Monitor cell metabolism and cellular response in real time with the label-free calorimetry based calScreener™ from SymCel.
calScreener™
calScreener™ is the first commercially available multi-channel calorimetric system developed for cell based assays. Measurement of heat flux in living cells is a well established and proven technology to monitor changes in metabolic processes. calScreener™ provides the researcher with a label-free detection tool with minimal or no assay development needed.
The versatility and speed makes calScreener™ suitable for a wide range of metabolic assay applications. calScreener™ detects changes in metabolic rate induced by addition of chemical- or biological compounds and provides a direct measurement of the resulting cellular processes. There is no need to have prior knowledge of metabolic pathways or mechanism of action to screen the effects of substances.
calScreener™ Advantages:
- First Calorimeter designed for cell biological work
- No assay formulation needed
- Measures heat from cell metabolism
- Label-free assay – no additives
- Prior knowledge of pathways and specific target function not needed
- Multiple compounds can be tested simultaneously for synergetic effects without knowledge of pathway interactions
- Suitable for a wide range of applications
calScreener™ Key Features:
- 48 well standard plate size adapted format
- Assay independent -no development needed
- Cell type independent
- Target independent
- Medium throughput format
- Analysis software solution provided
SymCel calScreener™ Technology
The calScreener™ system from SymCel provides researchers with a novel tool to measure the cellular metabolic response in a native environment.
calScreener™ is based on the measurement of thermogenic response in cultivated cells and is not dependent on any specific or cumbersome assay formulation. Since no addition of substrates or knowledge of the specific pathway or target is needed the time to results is greatly reduced as well as the cost for obtaining data.
The label-free principle of obtaining data makes calScreener™ suitable for a wide range of cell-science applications. calScreener™ can be used a screening tool applicable to different biological systems. Any types of cultivated cells as well as yeast or bacterial cultures are possible to use. calScreener™ measures thermal power which directly describes the metabolic rate. Both anabolic and catabolic processes are monitored.
The calorimetry principle is based on measuring the heat production changes induced by changes in the metabolism by chemical intervention of biological processes. Also other types of induced processes such as over-expression of proteins for pharmaceutical production, creates changes in the thermal output and can thus be monitored.
calScreener™ can be used for several types of applications where changes in metabolic rate are expected e.g. compound screening, lead substance optimization, bioavailability studies, cellular toxicity studies, biopharmaceutical process optimization, and antibiotics development.
calScreener™ is a complete assay solution with integration all the way from cell culture consumables to the measurement step and finally data analysis software.
